Biophysical mechanism for ras-nanocluster formation and signaling in plasma membrane.
Ras GTPases are lipid-anchored G proteins, which play a fundamental role in cell signaling processes.Electron micrographs of immunogold-labeled Ras have shown that membrane-bound Ras molecules segregate into nanocluster domains.Several here models have been developed in attempts to obtain quantitative descriptions of nanocluster formation, but all